About Stoke:
Stoke Therapeutics (Nasdaq: STOK) is a biotechnology company dedicated to restoring protein expression by harnessing the body’s potential with RNA medicine. Using Stoke’s proprietary approach, the company is developing antisense oligonucleotides (ASOs) to selectively restore naturally occurring protein levels. Stoke’s first medicine in development, zorevunersen, has demonstrated the potential for disease modification in patients with Dravet syndrome and is currently being evaluated in a Phase 3 study. Stoke entered into a strategic collaboration with Biogen in 2025 to develop and commercialize zorevunersen for Dravet syndrome. Under the collaboration, Stoke retains exclusive rights for zorevunersen in the United States, Canada, and Mexico; Biogen receives exclusive rest of world commercialization rights
STK-002 is Stoke’s proprietary antisense oligonucleotide (ASO) in clinical development for the treatment of autosomal dominant optic atrophy (ADOA), the most common inherited optic nerve disorder. STK-002 has been granted orphan drug designation by the FDA. A Phase 1 study (OSPREY) of STK-002 in people with ADOA is now underway. The company is also conducting early research in Syngap1, a severe and rare neurodevelopmental disorder, in collaboration with Acadia Pharmaceuticals.
Stoke’s initial focus is on diseases of the central nervous system and the eye that are caused by a loss of ~50% of normal protein levels (haploinsufficiency). Proof of concept has been demonstrated in other organs, tissues, and systems, supporting broad potential for the Company’s proprietary approach.
Position Purpose:
The role of the Director, Program Management is to partner with the development Program Leader to drive program planning and execution. The Director will be responsible for providing a combination of drug development, global commercialization, financial, and program management expertise to the Program Team (PT). This role, through partnership with the Program Leader, has significant responsibility for developing, driving, operationalizing, and executing program strategy. The candidate will have prior successful experience managing cross-functional teams in drug development. This individual will also be a strong influencer who can integrate multiple perspectives effectively, align stakeholders across functions and organization levels, problem-solve and achieve the program goals. This position will report into the SVP, Program Leadership and Management.
Key Responsibilities:
- Develop and maintain the integrated program plans, translating development strategy into actionable timelines, milestones, decision points and cross-functional deliverables.
- Partner closely with the Program Leader to ensure the PT operates efficiently, enabling clear priorities, informed decision-making, and forward planning.
- Drive program execution by tracking progress against key milestones, identifying emerging risks or dependencies, and facilitating proactive mitigation strategies.
- Ensure cross-functional alignment across development subteams by coordinating planning, surfacing trade-offs, and clarifying accountabilities.
- Lead program-level risk identification and mitigation planning, maintaining visibility of key program risks and ensuring they are actively managed by the appropriate teams.
- Prepare program materials and insights for governance discussions, ensuring leadership has clear, concise information to support strategic decisions.
- Facilitate effective program team meetings and decision processes, ensuring discussions focus on critical issues, decisions, and execution priorities.
- Support resource and scenario planning with functional leaders to ensure program plans are achievable and appropriately resourced.
- Partner with Alliance Management to coordinate collaboration partner interactions, supporting operational alignment, joint governance preparation, and tracking of shared deliverables when applicable.
- Maintain clear communication of program status, key risks, and upcoming decisions to stakeholders across the organization.
- Enable effective operation of the PT by driving integration, alignment, and execution across functional subteams throughout the development lifecycle.
Required Skills & Experience:
- Minimum of 10 years total experience in pharmaceutical or biotechnology industry including participation on cross-functional drug development teams.
- BA/BS degree required; advanced medical, scientific or business degree strongly preferred.
- Strong understanding of the drug development lifecycle, including clinical development planning, regulatory milestones, and cross-functional dependencies.
- Demonstrated ability to drive complex programs forward in a matrixed environment, balancing strategic thinking with operational execution.
- Proven experience integrating cross-functional input into clear, actionable program plans and enabling teams to deliver against shared goals.
- Strong facilitation and communication skills, with the ability to guide discussions, clarify decisions, and align diverse stakeholders.
- Ability to anticipate program challenges and proactively develop mitigation strategies.
- Excellent organizational and analytical skills, with the ability to synthesize complex information into clear insights for leadership.
- Collaborative leadership style with strong relationship-building skills across functions and external partners.
- Experience supporting alliance or collaboration programs is a plus.
Location(s):
Stoke is located in Bedford, MA, and will be moving to a new location in Waltham, MA by the end of 2026. This position is a hybrid position currently based in Bedford and will later be based in Waltham.
Travel:
This position will require approximately 20% travel.
Compensation & Benefits:
At Stoke Therapeutics, we are committed to offering a comprehensive, competitive and thoughtfully designed total rewards program.
The anticipated salary range for this role is
$192,000 - $218,000. The final offer will be determined based on a variety of factors, including role scope, experience and qualifications, education, market benchmarks, internal equity, and geographic location. In addition to base salary, Stoke offers an annual bonus and equity participation.
Our benefits package includes medical, dental and vision insurance; life, long- and short-term disability insurance; paid parental leave; a 401K plan with company match, unlimited vacation time, tuition assistance and participation in our Employee Stock Purchase Program (ESPP).
Culture & Values:
At Stoke, we believe that innovation, the ability to successfully advance our ground-breaking science and having fun as a team are enhanced by being together in person, at least periodically. We allow for flexibility in work arrangements that balance individual’s needs and preferences with the needs of our business and our desire to foster a culture of collaboration and innovation.
Our values guide our work to deliver meaningful medicines for people who need them. We are committed to being true to ourselves, to our colleagues, and to the people with severe diseases who are counting on us. We embrace diversity within a unique culture that is defined by our values. Our employee-led Diversity, Inclusion, and Belonging (DIB) Committee underscores the importance of DIB to who we are and what we do.
Interested candidates: Please visit Stoke’s website to learn more and apply directly to the position listed on our Career Center:
https://www.stoketherapeutics.com/careers/
For more information, visit https://www.stoketherapeutics.com/.
All applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, physical or mental disability or protected veteran status.
Stoke participates in E-Verify.
