About Stoke:

Stoke Therapeutics (Nasdaq: STOK) is a biotechnology company dedicated to restoring protein expression by harnessing the body’s potential with RNA medicine. Using Stoke’s proprietary approach, the company is developing antisense oligonucleotides (ASOs) to selectively restore naturally occurring protein levels. Stoke’s first medicine in development, zorevunersen, has demonstrated the potential for disease modification in patients with Dravet syndrome and is currently being evaluated in a Phase 3 study. Stoke entered into a strategic collaboration with Biogen in 2025 to develop and commercialize zorevunersen for Dravet syndrome. Under the collaboration, Stoke retains exclusive rights for zorevunersen in the United States, Canada, and Mexico; Biogen receives exclusive rest of world commercialization rights

STK-002 is Stoke’s proprietary antisense oligonucleotide (ASO) in clinical development for the treatment of autosomal dominant optic atrophy (ADOA), the most common inherited optic nerve disorder. STK-002 has been granted orphan drug designation by the FDA. A Phase 1 study (OSPREY) of STK-002 in people with ADOA is now underway. The company is also conducting early research in Syngap1, a severe and rare neurodevelopmental disorder, in collaboration with Acadia Pharmaceuticals.

Stoke’s initial focus is on diseases of the central nervous system and the eye that are caused by a loss of ~50% of normal protein levels (haploinsufficiency). Proof of concept has been demonstrated in other organs, tissues, and systems, supporting broad potential for the Company’s proprietary approach.

Position Purpose:

Stoke is seeking an enthusiastic and highly motivated Research Associate to join the In Vivo Pharmacology Department. This position is an opportunity to learn new techniques and concepts, be creative, and grow with a growing company. This position will report into a Senior Scientist.

Key Responsibilities:

Support the execution of routine studies to investigate the PK/PD of drug candidates.
Perform routine animal procedures including handling, restraint, clinical observations, dosing, sample collection, and necropsy.
Perform RNA and protein analysis, including techniques such as qPCR, Western blotting, and related assays
Read and understand scientific literature.
Maintain accurate, complete, and timely documentation of experimental procedures, observations, and study results.
Analyze data, author technical reports, and maintain accurate experimental records and document results in electronic lab notebooks
Participate and present at project team and departmental meetings.
Collaborate closely with scientists across pharmacology, biology, and translational research teams

Required Skills & Experience:

S with 2 years post-graduate experience working in a biotechnology or pharmaceutical company or contract research organization or a M.S.
Experience with mouse handling and in vivo procedures; intracerebroventricular injection experience a plus.
Experience with molecular biology assays such as PCR, MSD, Western Blot (or JESS).
Strong organizational skills and attention to detail.
Strong verbal and written communication skills.
Creative thinking and working well in a team environment.
Experience in neuroscience a plus.
Experience with ISH/IHC a plus.

Location(s):

Stoke is located in Bedford, MA, and will be moving to a new location in Waltham, MA by the end of 2026. This lab-based position is currently based in Bedford and will later be based in Waltham.

Travel:

This position will require approximately 0% travel.

Compensation & Benefits:

At Stoke Therapeutics, we are committed to offering a comprehensive, competitive and thoughtfully designed total rewards program.

The anticipated salary range for this role is $92,000 - $99,000. The final offer will be determined based on a variety of factors, including role scope, experience and qualifications, education, market benchmarks, internal equity, and geographic location. In addition to base salary, Stoke offers an annual bonus and equity participation.

Our benefits package includes medical, dental and vision insurance; life, long- and short-term disability insurance; paid parental leave; a 401K plan with company match, unlimited vacation time, tuition assistance and participation in our Employee Stock Purchase Program (ESPP).

Culture & Values:

At Stoke, we believe that innovation, the ability to successfully advance our ground-breaking science and having fun as a team are enhanced by being together in person, at least periodically. We allow for flexibility in work arrangements that balance individual’s needs and preferences with the needs of our business and our desire to foster a culture of collaboration and innovation.

Our values guide our work to deliver meaningful medicines for people who need them. We are committed to being true to ourselves, to our colleagues, and to the people with severe diseases who are counting on us. We embrace diversity within a unique culture that is defined by our values. Our employee-led Diversity, Inclusion, and Belonging (DIB) Committee underscores the importance of DIB to who we are and what we do.

Interested candidates: Please visit Stoke’s website to learn more and apply directly to the position listed on our Career Center:

https://www.stoketherapeutics.com/careers/

For more information, visit https://www.stoketherapeutics.com/.

All applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, physical or mental disability or protected veteran status.

Stoke participates in E-Verify.

Stoke Therapeutics

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