Position Title: Research Associate II
Reports To: Scientist II
Location: Cambridge, MA
Join the adventure!
CAMP4 is leveraging a proprietary drug discovery platform to discover antisense oligonucleotides (ASOs) targeting regulatory RNAs to treat a broad range of central nervous system diseases. We are seeking a passionate Research Associate II to join the Discovery team responsible for driving a pipeline of programs. You will work closely with the Platform, Chemistry, Data Science, and Preclinical teams to generate data supporting the advancement of pipeline projects. A key responsibility for this role will be to support our in vivo pharmacology and efficacy studies to evaluate candidate ASOs. A successful candidate will apply their experience in tissue processing including RNA and protein extraction and quantification to characterize the effects of candidate ASOs on target engagement and phenotypic rescue. This is an exciting opportunity for a self-motivated, team-oriented, and collaborative individual with outstanding organizational and communication skills. Title commensurate with experience.
Key Responsibilities:
- Analyze in vivo pharmacology and efficacy studies by processing mouse tissue samples for RNA and protein (no direct animal work).
- Execute and optimize workflows for tissue collection, homogenization, RNA/protein extraction, and downstream assays to ensure high-quality, reproducible data.
- Support evaluation of ASO activity on RNA/protein in iPSC-derived neurons.
- Assist in development and execution of biochemical (e.g., ELISA) and/or cellular functional assays (e.g., multielectrode array) for target validation and to assess ASO activity.
- Provide input into experimental design, data analysis, and communication of results to the broader scientific teams.
- Maintain detailed records of experimental design and results in electronic lab notebook.
- Support daily laboratory operation and maintenance including preparing and ordering necessary reagents and supplies, equipment maintenance, and other periodic lab activities.
Qualifications:
Education & Experience
- BS or MS degree in neuroscience, cell biology, molecular biology or a similar discipline with 2+ years of industry or academic research experience.
- Experience with molecular biology techniques including RNA isolation, QPCR, and western blot. Experience with immunofluorescence staining, microscopy, and ELISAs is preferred.
Skills & Competencies
- Demonstrated expertise in cell culture experimental skills; primary cell and human iPSC cell culture experience is preferred.
- Team-oriented, highly motivated with a strong work ethic, ability to work productively in a fast-paced collaborative environment that requires a high level of organization and communication.
- Demonstrated attention to detail and time management skills.
Compensation and Benefits:
At CAMP4 Therapeutics, we offer a competitive and thoughtfully designed total rewards program. The anticipated salary range for this role is $85,000.00 - $110,000.00. Base salary offered is determined through an analytical approach utilizing a combination of factors including, but not limited to, relevant skills & experience, job location, and internal equity. In addition to base salary, employees are eligible to receive an annual bonus and equity incentive opportunities.
Our benefits include medical, dental, and vision insurance; life and disability coverage; paid parental leave; a 401(k) plan with company contribution; Employee Stock Purchase Program, Trek Time (flexible time off); tuition assistance; and additional perks that support your well-being and professional growth.
About CAMP4:
CAMP4 is developing disease-modifying treatments for a broad range of genetic diseases where amplifying healthy protein may offer therapeutic benefits. Our approach amplifies mRNA by harnessing a fundamental mechanism of how genes are controlled. To amplify mRNA, our therapeutic ASO drug candidates target regulatory RNAs (regRNAs), which act locally on transcription factors and are the master regulators of gene expression. CAMP4’s proprietary RAPTM Platform enables the mapping of regRNAs and design of optimal chemistry to generate potent therapeutic candidates to address hundreds of genetic diseases across multiple tissues. Learn more about us at www.camp4tx.com and follow us @CAMP4tx.
