Clinical Trial Manager

Candel Therapeutics • Full-time • Needham, MA, US • 3m ago

Why Work With Us?At Candel Therapetics, our people drive our success. We value diversity, collaboration, and bold thinking in a supportive, mission-driven environment. Like a team, we show up for each other and stay focused on making a difference for patients and families. Our leadership is transparent and empowering, and our culture is built on trust, flexibility, and accountability, encouraging ownership and innovation every day.Our Science: Advancing Cancer ImmunotherapiesCandel Therapeutics is a clinical-stage biopharma company developing off-the-shelf, multimodal immunotherapies that stimulate personalized, systemic anti-tumor responses. Our platforms use genetically modified adenovirus and HSV constructs. With positive Phase 3 results for our lead candidate, it’s an exciting time to join us and help bring transformative cancer treatments to patients. Learn more: www.candeltx.comPosition Summary:We’re looking for a Clinical Trial Manager (CTM) to help us lead execution of our Phase 3 oncology trials with precision, confidence, and heart. This is a fast-paced, high-accountability role where you’ll collaborate cross-functionally, ensure inspection readiness, and keep our clinical operations running smoothly.
If you’re a self-motivated leader who thrives on solving problems, navigating complexity, and working with humility, this role is for you.What You’ll Do:

Provide operational management and leadership to cross-functional study team to execute the clinical study per agreed upon timelines, budget and quality.
Drive startup through closeout: IRB, contracting, site selection, initiation, monitoring, and metrics tracking.
Support inspection readiness and contribute to critical regulatory milestones.
Co-monitor with CRAs; review site visit reports and escalate issues proactively.
Maintain essential documents and trial master file (TMF) accuracy.
Collaborate with internal teams and vendors to ensure alignment and effective execution.

What You Bring:

4+ years of CTM or site management experience in oncology clinical trials is required
Deep understanding of Phase 3 trial conduct and in-house operational models
Familiarity with ICH/GCP, FDA/EMA guidelines, and regulatory best practices
Strong leadership and problem-solving skills; ability to manage ambiguity and prioritize independently
Exceptional communication skills and comfort interacting with senior stakeholders
Prior CRA experience is a plus
High emotional intelligence and a “scrappy but humble” mindset

Why You’ll Succeed at Candel:

You know how to get things done without needing step-by-step instructions
You value collaboration over ego and strive to lift others as you grow
You’re excited to join a growing company and make a tangible impact
You care about patients, science, and people—in that order

Work Environment:This is a hybrid position based in the Greater Boston area. Onsite presence of 1–2 days/week is expected. Occasional travel (~20%) may be required for site co-monitoring or inspections.

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