Pharvaris is a late-stage biopharmaceutical company developing novel, oral bradykinin B2 receptor antagonists to potentially address all types of bradykinin-mediated angioedema. By targeting this clinically proven therapeutic target with novel, oral small molecules, the Pharvaris team is advancing new alternatives to injected therapies for the prevention and treatment of hereditary angioedema (HAE) attacks, and other bradykinin B2-receptor-mediated indications. HAE is a rare and potentially life-threatening genetic disease and people living with HAE can suffer sudden and prolonged attacks of swelling in multiple areas of the body, including the airway, which can be life-threatening.

We are expanding our U.S. Commercial team and are looking for a Zone Directors to join our team and report to our VP, Head of Sales & Marketing.

As the Zone Director you will be hiring and leading a team of approximately 8-10 Area Business Managers (ABMs) for the launch of Deucrictibant IR & XR in the rare disease market. The Zone Director will be building and leading a high-performance sales team, driving market adoption, and executing a best-in-class commercial strategy in an ultra-competitive landscape.

This is an opportunity to lead from the front, ensuring that our sales team is fully prepared to engage, compete, and win in the rare disease space. The ideal candidate is a proven leader, capable of inspiring, coaching, and holding a team accountable for results while maintaining a deep understanding of physician practice operations, payer dynamics, and competitive differentiation.

Location
At Pharvaris we promote and enable a flexible hybrid work environment, where our employees choose from where (and to some extent when) they prefer to work. Whilst this is a remote/hybrid role, you need to be in U.S. and able to support one of the zones, Northeast, Southeast, West or Central.

Responsibilities
Sales Leadership & Performance Management

Hire, develop, and lead a team of 8-10 Area Business Managers (ABMs)
Establish and maintain a high-performance sales culture driven by accountability, execution and competition
Ensure that all team members are set up for success and are equipped to consistently meet or exceed sales targets
Serve as a front-line leader, modeling best-in-class sales execution and objection handling

Strategic Market Execution

Develop and execute territory strategies that maximize market penetration and growth
Translate corporate and brand strategy into tactical field execution
Ensure field insights are consistently fed back to cross-functional teams to optimize strategy
Leverage data and analytics tools to drive business decisions and maximize field performance

KOL & Stakeholder Engagement

Establish and maintain long lasting relationships with Key Opinion Leaders (KOLs) and top prescribers in the region
Partner with Market Access, Patient Services, and Medical Affairs to optimize payer pull-through and patient access
Develop strategies to increase disease awareness and brand adoption in targeted accounts

Field Sales Training & Team Development

Assist in facilitating sales training programs focused on disease state knowledge, clinical differentiation, and reimbursement dynamics
Conduct field coaching and real-time training, ensuring all ABMs are market-ready
Lead by example—demonstrating coaching skills in live customer engagements

Sales Force Effectiveness & Execution Discipline

Ensure all sales activities are executed with precision, consistency, and compliance
Utilize CRM (Salesforce) and FSR platforms to track performance, measure KPIs, and drive accountability
Monitor and refine team execution based on real-time market insights and competitive intelligence

Ownership Mentality & Travel Requirements

Own the number—demonstrate accountability for regional performance
Up to 70% Travel
Foster a culture of resilience, adaptability, and problem-solving under pressure

Requirements

Bachelor’s degree required
Proven rare disease sales leadership experience (Minimum 3+ years in leadership roles)
Track record of hiring, developing, and managing successful sales teams
Strong business acumen & deep understanding of market access, payer dynamics, and reimbursement
Exceptional KOL & stakeholder engagement skills—ability to build deep, strategic relationships
Competitive, high-energy, and execution-focused mindset
Ability to model best-in-class sales skills and coach teams to excellence
Strong communication & influence skills—comfortable leading from the front
Field-first leadership approach—willing to travel and lead in-market
Comfortable working in a fast-paced, evolving environment with an entrepreneurial mindset.

Pharvaris is committed to fair and equitable compensation practices. The base salary range for this role is $210,000-$245,000 per year. Actual compensation will depend on various factors, including but not limited to depth of experience, skill set, overall performance, and education. Pharvaris believes in providing a competitive compensation and benefits package. Base salary is just one component of our competitive total rewards strategy. In addition to compensation, this role offers the unique opportunity to help build and shape an early-stage commercial organization, meaningful ownership through equity, sales incentives, workplace flexibility, and flexible time off. We encourage candidates who are motivated by the full opportunity and alignment with our mission to apply, even if their current compensation falls outside the stated range.

Pharvaris

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