Research Associate/Senior Research Associate - Process Development

About Ernexa Therapeutics:

Ernexa Therapeutics (NASDAQ: ERNA), is a preclinical stage company developing off-the-shelf, synthetic, induced pluripotent stem cell (iPSC)-derived mesenchymal stem cell (iMSC) therapies. Our mission is to transform the treatment of cancer and autoimmune disease by developing scalable, affordable, off-the-shelf cell therapies that restore hope. Our lead product candidate, ERNA-101, expresses an IL-7_IL-15 fusion cytokine, designed to activate and regulate the immune system's response to recognize and attack cancer cells. The company’s initial focus is to develop ERNA-101 in platinum-resistant ovarian cancer (PROC). The company is also investigating ERNA-201, anti-inflammatory cytokine (IL-10)-secreting iMSCs in inflammatory/autoimmune disorders like rheumatoid arthritis.

Position description:

Ernexa Therapeutics is seeking a talented and motivated Research Associate/ Senior Research Associate to join the Process Development team. The individual will work closely with team members to develop GMP-compatible processes and procedures that will lead to the effective manufacture of our cell therapy products. This position will report into a Director who is leading the technical development of a GMP-enabling cell therapy manufacturing process and associated analytical methods. The individual will also interact cross-functionally across the organization to enable the success of Ernexa Therapeutics.

What you will do:

Support development and optimization of manufacturing processes for induced pluripotent stem cell (iPSC) therapies, focusing on cell reprogramming, differentiation, scale-up
Perform laboratory tasks such as maintaining and culturing iPSCs, differentating iPSCs, developing and refining protocols
Run flow cytometry analyses and functional assays, as needed
Assist with planning, execution, analysis, and reporting on experiments and analytic assays to support the development of a GMP process to manufacture, characterize and release stem cell therapy products.
Compile documentation (protocols, batch records, reports) to facilitate transfer of Ernexa Therapeutics’ process and methods to external CDMO
Collaborate closely with other functions to enable effective and successful project execution
Organize, communicate, and present complex data sets to key stakeholders and senior management
Assist cross-functional activities including hand-offs to various teams, compiling data, and presenting at project meetings

What you will bring:

Bachelors or Masters degree in Cell Biology, Immunology or the biological sciences
0-2+ years of relevant research experience in cellular therapeutics and/or immunotherapy
Prior experience in cell therapy, industry, and process development experience preferred
Expertise in cell handling, cell expansion, and mammalian cell culture techniques preferred
Experience in multi-color flow cytometry analyses, including panel design and data analysis preferred
Expertise in cell functional assays including proliferation assessment, cytotoxicity, cytokine/chemokine
Ability to quickly adapt and learn new skills for changing research priorities
Flexible mind with the ability to think outside the box, creative approach to problem-solving
Demonstrated ability to work well in a highly collaborative team environment, coordinate tasks across multiple projects to meet deadlines

Ernexa Therapeutics

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Research Associate/Senior Research Associate - Process Development